September 26, 2023
This article explores the mysterious disease that claims Frank's life in The Last of Us, providing an in-depth analysis of the symptoms, causes, and progression of the disease. It also dives deeper into the implications of Frank's illness in the game's plot and themes.


The Last of Us is an action-adventure game that takes place in a post-apocalyptic world where most of humanity is wiped out due to the Cordyceps fungus infection. One of the characters in the game, Frank, is portrayed as suffering from a disease. This disease plays a critical role in the game’s plot and raises several questions about the illness and its effects on the human body. In this article, we will explore the details of Frank’s disease in The Last of Us, including its symptoms and causes, and examine its implications in the game’s plot and themes.

The Mysterious Disease Affecting Frank in The Last of Us

Frank is a character in The Last of Us, who dies early in the game. He is first introduced by Joel, who mentions that he was a friend and a former partner in the smuggling trade. The game hints at Frank’s mysterious illness, which is instrumental in his death. The fact that Frank was infected by the Cordyceps fungus and was slowly losing his mind raises various questions about the nature of his condition and how it was different from the standard infection.

Exploring the Symptoms and Causes of Frank’s Illness in The Last of Us

Frank’s physical symptoms are subtle at first but become more pronounced as the game progresses. Players can see that Frank is having difficulty remembering things and getting his words out, which are early signs of the infection’s impact on the mind. He also has tremors and is unable to hold his hands still, which suggest a progressive neurological disorder.

As for the causes of the illness, the game is vague and raises more questions than answers. The fact that Frank is infected by the Cordyceps fungus but clearly has a different manifestation of the infection suggests that there are other viral strains present that cause unique symptoms and progression.

Unraveling the Truth Behind the Infection that Claimed Frank’s Life in The Last of Us

The Cordyceps fungus is the cause of the infection that destroys human hosts in The Last of Us. When spores from the fungus enter the body through the lungs, they infect and invade the cells of the host. The fungus hijacks the physiology of its host, causing the body’s immune response to dampen, thus allowing the infection to spread unchecked.

Once the Cordyceps fungus infects the brain, it results in a severe neurological disorder that makes the host lose their mind slowly and progressively. The spores feed off the brain’s tissue, resulting in host’s loss of motor functions, motor control, and memory. This means that anyone infected by this particular strain of the Cordyceps fungus would ultimately perish, implying that Frank’s survival chances were almost non-existent.

A Closer Look at the Ravaging Disease that Proves Deadly in The Last of Us

The Cordyceps fungus’s progression in the human body is gradual, yet it proves to be fatal. The fungus infects the host’s lungs first, which leads to breathing difficulties and persistent coughing. The infection then spreads to the brain, causing severe neurological damage in the form of memory loss, tremors, and loss of motor function. Eventually, the infection reaches a critical point where the host can no longer survive, prompting their death.

Piecing Together the Puzzle of Frank’s Disease and its Implications in The Last of Us

The implication of the disease that claims Frank’s life is enormous, particularly in the context of The Last of Us’s plot and themes. The disease reduces human beings to their most primitive state, rendering them incapable of rational thought, memory, and motor control. This condition reflects The Last of Us’s worldview, where humanity is on the brink of extinction and the world is in regression. Frank’s disease highlights the reality of the game’s world and shows what awaits the infected survivors of the apocalypse.


Frank’s illness in The Last of Us draws attention to the perilous nature of illness and disease, particularly in a world where medical resources are scarce or non-existent. It highlights the reality of living in a world where basic necessities such as food, water, and healthcare are either limited or non-existent. It also raises important questions about how a disease can impact human beings, both physically and mentally.

Understanding the disease that claims Frank’s life is crucial to the player’s enjoyment and understanding of The Last of Us’s world. It also shows the importance of medical knowledge and the role it plays in preserving human life.

To that end, The Last of Us is a game that highlights the importance of safeguarding our health and lives and the devastating consequences of neglecting them.

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