February 29, 2024
Choline plays a crucial role in the human body, and a deficiency in this nutrient could lead to various health complications. This article outlines what choline is and its classification as a vitamin, the benefits to the body, and its essential role in liver function, the brain, pregnancy, and age-related cognitive decline.


Choline is a vital nutrient that is often overlooked and underrated. It is a nutrient that is needed by the body to function properly. Although it could be produced by the body, choline is mostly consumed through the diet. Choline is classified as a vitamin by some, while others dispute this classification. In this article, we will explore choline, its benefits, and its classification as a vitamin.

Defining Choline as a New Essential Nutrient

Choline is an essential nutrient that is required for the proper functioning of the body. It is similar to vitamins in that it is not produced by the body in sufficient amounts making it essential to get from the diet. It is classified as a methyl donor, which means that it contributes methyl groups necessary for various bodily processes. The body uses choline to produce membrane phospholipids, which are crucial for cell structure as well as signaling. Choline is also involved in the synthesis of the neurotransmitter acetylcholine, which is essential in supporting cognitive function and controlling muscle movement.

Choline has a metabolic role in the body and is naturally present in a variety of foods. Humans can also produce choline in the liver which is why, initially, it was not classified as a vitamin. However, it was not long before researchers realized that the liver’s capacity to provide choline is not sufficient to meet the body’s needs. Choline was, therefore, reclassified as a vitamin-like compound that the body can produce but in amounts that are insufficient for normal physiological function.

Choline is essential for proper liver function, synapse formation in the brain, and healthy fetal development, among other functions. Without adequate levels of choline, the body cannot form cell membranes or produce neurotransmitters necessary for proper cognitive functioning, organ growth, and maintenance.

Choline and Brain Health

One of the most conspicuously key roles of choline is in the development and function of the brain. Inadequate choline intake during development can lead to various neurological disorders. Choline plays a crucial role in the development and maintenance of the brain. It is a component of acetylcholine, a neurotransmitter that is critical to maintaining cognitive function. A deficiency in choline can lead to a decline in the production and release of acetylcholine, which will result in a decline in cognitive function. Studies on animals have shown that a lack of choline in the diet led to memory impairment. They have also shown that cognitive problems can be reversed with increased choline intake.

Choline and Liver Health

Choline is necessary for liver function and fat metabolism. The liver cannot produce choline in sufficient amounts leading to a deficiency in the body. A deficiency in choline can result in liver damage over time, which could lead to diseases such as non-alcoholic fatty liver disease (NAFLD). The liver stores fats, makes bile, and aids in the metabolism of medications and toxins. High-fat diets may lead to liver disease in the long run. Choline can be used to reduce this risk. Choline depletion alters lipid metabolism in the liver leading to NAFLD and liver fibrosis. Studies have also shown that low choline intake is associated with chronic liver disease.

Choline and Pregnancy

During pregnancy, choline is especially essential, as it is required by the fetus for healthy growth and development. Choline helps form the neural tube and boosts fetal brain development. A lack of choline in the diet during pregnancy can cause neural tube defects in the fetus. Studies have shown that pregnant women who consume enough choline have infants with better brain function and memory. Choline intake should, therefore, be a prime feature of the diet of pregnant women. The recommended daily intake (RDI) of choline for pregnant women is 450 mg/day.

Choline-rich foods such as eggs, liver, and salmon should be included in their diets as much as possible. Lecithin, the richest dietary source of choline, is present in soybeans, eggs, liver, and beef.

Choline and Age-Related Cognitive Decline

Intake of choline is associated with improved cognitive function and memory to help combat the decline experienced as one ages. This cognitive decline arises from the natural aging process and by the free radicles generated through smoking and other environmental factors. Research has shown that an increased intake of choline could prevent age-related cognitive decline by providing a sufficient quantity of choline in the diet. Clinical studies have found that adults with higher choline levels in their blood have better cognitive scores, memory, and recall functions than those with lower levels. A study found that taking choline supplements can improve cognitive functioning in adults aged between 50-85 years old.

Choline-Rich Foods

Choline can be derived from both animal and plant sources, with some options having much higher amounts of choline than others. The RDI for choline is 425-550 mg/day. Foods with some of the highest levels of choline include egg yolks, liver, beef, chicken, fish, legumes, grains such as quinoa and amaranth, and vegetables such as brussels sprouts and broccoli.

A lack of choline can lead to fatty liver disease, cognitive decline and increased damage to DNA since it is required for normal cell membrane function. However, the absence of choline deficiency does not mean that enough choline is available to provide the essential function of this nutrient. Choline-rich foods and supplements are the best way of increasing choline intake in the diet.


Choline, once overlooked and classified as a non-essential nutrient is now classified as a vitamin-like essential nutrient. Choline is vital for the body and essential for proper liver and cognitive function. An inadequate supply of choline has been associated with liver disease, cognitive decline, and developmental abnormalities. This nutrient is necessary not only during fetal development but also during aging to slow down cognitive decline and maintain brain function. Increasing the consumption of choline-rich foods and supplements will help prevent choline deficiency.

It is time for this essential nutrient to come to the limelight and receive the recognition that it deserves for the role it plays in the body. Paying attention to choline intake is crucial for people who want to attain optimal health throughout their lifespan.

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